Process of making compounds of the active substance of suprarenal glands, and said compounds.



UNITED" scmcrns PATENT OFFICE.

' 'Bnm'r' BEUTEB, or noonsr-oN-TI'm-MAIN, onnninny, ASSIGNOR, BY mnsnn A s- SIGNMENTS, TO THE FIRM or n. A. mn'rza 00., OF NEW YORK, n. Y.

of Makin PROCESS OF iimxme COMPOUNDS on THE ACTIVE suns'rancn oia surnanmmn cums, AND SAID courtrooms.

No Drawing.

Specification of Letters Patent. Patented Sept. Application filed December 1, 1903. Serial No. 183,371.

Be it known that I, BAPTIST siding at Hiichst-on-the-Main, German have invented a certain new and useful rocess Compounds of the Active Subr stance of uprarenal Glands, and Said Com- I obtained to dryness or only to a syrupy con? pounds, of which the following is a specification.

The base of the activesubstance of suprarenal lands decomposing at 207 C. is soluble with difiiculty in water and neutral aqueous liquids, but readily soluble in dilute acids. It has hitherto been used as free base (powder) or as salt solutions. These two forms, when practically employed, have various drawbacks. The stability of the salt solutions is limited, being of a certain concentration, unavoidable with every solution admitting of dilution but not of concentration. In using the base the difficulties increase, as it has first to be transformed into a suitable solution which requires exact work ing on the part of the physician, the presence of acids of certain degrees etc.

A want made itself felt for stable compounds of the active base readily soluble in Water. It may be obtained by evaporating the hydrochlorid or sulfate solutions of the base of 'suprarenal glands to solid compounds which, however, are too hydroscopic and decompose too readily in the air.

I have found that a solid compound of the suprarenal lands stable in air may be obtamed by dls'solvin the base in water while adding 1;; molecu ar proportions of boric acid and by evaporating the solution thus sistence and addin absolute alcohol, whereupon the boric acl compound of the suprarenal lands is precipitated in solid form.

It is t en dried and pulverized. The salt thus obtained .has the, active properties of the base of suprarenal glands. The boric acid compounds have the following properties. From a physiological oint of view they are equal to those of the ass in hydrochloric acid, without however, as the latter,

irritatif ig the tissues. :They separate no I REU'rnn, a citizen of the Empire of Germany, and rebase on addition of alkalies; on addition of ferric chlorid they turn violet andon a further addition of ferric chlorid they assume the characteristic een tint. The solid boric acid compoun of the base of suprarenal glands may be heated above the melt- 1ng point of the free base without decomposing or. losing its efficacy by which it is istinguished from a mixture of dry boric vacuum as considerable frothing occurs, un-

til the water is evaporated.

Having now described my invention, what I claim is i 1. As a new product, a solid compound produced by the union of one and one half (1%) 'molecules of boric acid and one (1) molecule of the base of the .suprarenal glands, stable in air, readily soluble 1n water and difiicultly soluble in alcohol, and having the physiological properties of the base of the suprarenal gland.

2. The herein-described process of producing a dry, stable substance containing the principle of the suprarenal glands, consisting in dissolvingv the base of said glands and boric acid in molecular proportions of one (1) to one and one-half (1%) in water I and then separating the boric acid compound of the base of the glands from the water.

3. The herein-described process of producing a dry, stable substance containing the principle of the suprarenal glands, consisting in dissolving the base of said glands and'boric acid in molecular proportions of one (1) and one and one-half (14 in water and then separating the boric acid compound of the base of the glands from the water by adding alcohol to said water so as to precipias my invention, I have signed my name in gate t his bolrate ofbthe base in {file fornlof a presence of two subscribing Witnesses. r cr stal ine su stance W ie is sta e in 1 r air re dily soluble in watelypand possesses BAPE 1ST I 5 the physiological properties of the base of VVit the suprarenal glands. ALFREQ BRISBOIS,

In testimony; that I claim the foregoing BERNH'ARD LYDECKER. 

